Streptomycin-dependent Variants of Bact. coli Isolated from Patients during Treatment with Streptomycin

Streptomycin-dependent variants of Bact. coli isolated from patients during treatment with streptomycin.

Since the publication in 1947 of Miller and Bohnhoff's report on streptomycin-dependent meningococci, streptomycin-dependent variants of many other bacterial species have been isolated and studied in vitro (Paine and Finland, 1948; Kushnick, Randles, Gray, and Birkeland, 1947; Yegian, Budd, and Vanderlinde, 1949). Miller and Bohnhoff also showed streptomycin-dependence in vivo when mice infecte...

Effects of streptomycin deprivation on enzyme synthesis in streptomycin-dependent Escherichia coli.

During growth of streptomycin-dependent strains of Escherichia coli in the absence of streptomycin (deprived growth), both constitutive and inducible synthesis of beta-galactosidase were preferentially inhibited. A similar preferential inhibition of constitutive and derepressed synthesis of alkaline phosphatase was observed. Catabolite repression accounted for part, but not all, of the inhibiti...

Treatment of gonorrhoea with streptomycin.

Although a number of papers on the treatment of gonorrhoea with streptomycin have been published during the last four years, few reports have come from Great Britain. Chinn and others (1947) obtained seventy cures out of 72 patients who were given 0-2 to 0-5 g. streptomycin, and Pulaski (1947) reported success in nine cases. Willcox (1948), employing a single injection of 0-2 to 0-6 g. had succ...

Regulation of acetohydroxy acid synthase in streptomycin-dependent Escherichia coli.

Growth of streptomycin-dependent mutants of Escherichia coli K-12 was insensitive to valine when dihydrostreptomycin was present in a nonlimiting concentration in glucose-salts medium. Acetohydroxy acid synthase was derepressed under these conditions, owing to relaxation of catabolite repression. Valine sensitivity and catabolite repression were restored when streptomycin-dependent E. coli K-12...

Treatment of tuberculous meningitis with streptomycin.